A post-docking role for active zone protein Rim
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چکیده
منابع مشابه
RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
At presynaptic active zones, neurotransmitter release is initiated by the opening of voltage-gated Ca²+ channels close to docked vesicles. The mechanisms that enrich Ca²+ channels at active zones are, however, largely unknown, possibly because of the limited presynaptic accessibility of most synapses. Here, we have established a Cre-lox based conditional knockout approach at a presynaptically a...
متن کاملLiu for Neurotransmitter Release RIM - Binding Protein , a Central Part of the Active Zone , Is Essential
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متن کاملRIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.
The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several essential components have been identified. AZ-associated protein scaffolds are viewed as only modulatory for transmission. We discovered that Drosophila Rab3-interacting molecule (RIM)-binding protein (DRBP) is essential not only for the integ...
متن کاملProtein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.
Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder precipitated by coffee, alcohol, and stress. We previously identified the causative gene but the function of the encoded protein remains unknown. We also generated a PNKD mouse model that revealed dysregulated dopamine signaling in vivo. Here, we show that PNKD interacts with synaptic active zone pro...
متن کاملFife, a Drosophila Piccolo-RIM homolog, promotes active zone organization and neurotransmitter release.
Neuronal communication depends on the precisely orchestrated release of neurotransmitter at specialized sites called active zones (AZs). A small number of scaffolding and cytoskeletal proteins comprising the cytomatrix of the active zone (CAZ) are thought to organize the architecture and functional properties of AZs. The majority of CAZ proteins are evolutionarily conserved, underscoring the fu...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2001
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn732